Half-Year 2022 Financial and Clinical Trials Update

HY 2022: Group operating free cash flow OFCF up by +21% driven by higher Operating Profit, net of cash adjustments CHFM 8,117 +29 +1 +606 -70 +1,099 OFCF higher by +21%/+1,735m at CER 9,782 HY 2021 OP, net of cash adjustments NWC movement Investments in PP&E Investments in IA CER = Constant Exchange Rates; OP = Operating Profit; NWC: Net Working Capital; PP&E = Property, Plant & Equipment incl. increase of lease liability paid; IA = Intangible Assets Foreign HY 2022 exchange Roche 64

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