Half-Year 2022 Financial and Clinical Trials Update

HY 2022: Group Core tax rate Tax rate before resolution of tax disputes increased due to higher profits in higher tax jurisdictions Roche +0.8%p 18.5% 17.7% 0.8% 2.4% Reduction in the effective tax rate from the resolution of tax disputes Tax rate before resolution of tax disputes 16.9% Effective tax rate HY1 2021 -0.8%p Effective tax rate as reported 16.1% Effective tax rate HY1 2022 60

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