Pharma Update

Evolution of our R&D engines, with impact on the full value chain Leveraging the newest technologies to bring unprecedented changes • Computational Biology, AI/ML and advanced computation Acceleration of biological insights Systematic discovery of targets and biomarkers More efficient target prioritization and development (efficacy, safety, tractability) Digital endpoints delivering new patient insights and building holistic solutions for patients • • • • Organoids: Creating reliable predictive models emulating the human body Roche launched the Institute of Human Biology (IHB) Engineering the most advanced organoids to explore physiology, understand diseases and develop new therapies Accelerate discovery and development of new medicines Core areas: exploratory research, bioengineering, translation & technologies Roche Leader Head of gRED Head of gRED Computation Aviv Regev John Marioni Head of PRED Hans Clevers Head of IHB Matthias Lütolf Roche New technologies enabling unprecedented changes along the full value chains of Pharma and Diagnostics 32 52

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