Q4 FY22 Earnings Presentation

Q4 FY22 Guidance and assumptions In line with Street consensus Table of Executive Portfolio Financial Guidance & Contents Summary Highlights Highlights Assumptions ESG Appendix Organic revenue growth Non-GAAP Total company . ~5.5% diluted EPS $1.56 to $1.58 . Foreign exchange¹ Approx. ($185M) Flat to slightly positive EPS guidance does not include any charges or gains that would be reported as non-GAAP adjustments to earnings during the fiscal year. ¹While FX rates are fluid, assumptions above are based on recent rates near the specific earnings call. 26 Q3 FY22 earnings presentation | February 22, 2022 Medtronic

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