Half-Year 2022 Financial and Clinical Trials Update

Exchange rate impact on sales growth Q2 2022: negative impact of JPY and EUR, positive impact of USD Development of average exchange rates versus prior year period CHF / USD CHF/EUR 2.2% 5.9% -4.9% -6.4% CHF/JPY -6.9% -10.6% Difference in CHF / CER -1.0% 0.4% growth Sales growth 2022 vs. 2021 11.2% 10.2% 0.0% 0.4% CER growth CHF growth Q1 Q2 Q3 80 CER = Constant Exchange Rates (avg full year 2021) Q4 Roche 201

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