40th Annual J.P. Morgan Healthcare Conference Presentation

2020 & 2019 Reconciliation Income from Operations and Net Income Reconciliation of GAAP Income from Operations to Non-GAAP (Adjusted) Income from Operations (Unaudited, amounts in thousands) GAAP Income from Operations Adjustments to Income from Operations Acquisition and integration costs Inventory step-up charges Intangible amortization Adjusted Income from Operations R REPLIGEN Twelve Months Ended December 31, 2020 2019 $ 69,823 $ 36,083 $ 11,465 $ $ 734 $ $ 16,032 $ $ 98,054 $ 12,508 1,483 13,441 63,515 Reconciliation of GAAP Net Income to Non-GAAP (Adjusted) Net Income (Unaudited, amounts in thousands) GAAP Net Income Adjustments to Net Income Acquisition and integration costs Inventory step-up charges Intangible amortization Loss on extinguishment of debt Non-cash interest expense Tax effect of non-GAAP charges Adjusted Net Income $ $ $ $ $ $ $ $ Twelve Months Ended December 31, 2020 59,926 $ 10,479 $ $ 16,032 $ $ 10,970 $ 734 (9,050) $ 89,091 $ 2019 21,411 13,008 1,483 13,441 5,650 7,536 (10,003) 52,526 20

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