Pharma Update

R&D focus area ophthalmology Better visual outcomes in the future via diagnostics and combination therapies Roche 5 Current SoC Anti-VEGF Anti-VEGF Anti-VEGF Personalized treatment options (PHC) Future SoC Biomarker analyses • Aqueous humor sample • Imaging . Aqueous humor • profiling . Clinical data Genotyping Up ि ه Machine learning algorithm " Clinical diagnosis support Atrophy • Prognosis Early diagnosis Drug choice Dosing regimen New combination therapies Inflammation Fibrosis Angiogenesis Ischemia Increased value for Healthcare ecosystems by delivering better care, improving efficiencies and optimizing resource utilization SoC-standard of care; VGEF-vascular endothelial growth factor; PHC-personalized healthcare 122

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