Q4 FY22 Earnings Presentation

Abbreviations & acronyms Business specific Table of Executive Portfolio Financial Guidance & Contents Summary Highlights Highlights Assumptions ESG Appendix Growth Business specific Other DD Double Digit AAA Abdominal Aortic Aneurysm GI Gastrointestinal $M Millions of Dollars LGBTQ HSD High-Single Digit ASGE American Society for Gastrointestinal Endoscopy ICD Implantable Cardioverter Defibrillator ΑΙ Artificial Intelligence MDR Other Lesbian, Gay, Bisexual, Transgender, Questioning Medical Device Regulations LDD Low-Double Digit AF Atrial Fibrillation LVAD Left Ventricular Assist Device APAC Asia Pacific N/A Not Applicable LSD Low-Single Digit AS Aortic Stenosis Ex-MCS Excluding Mechanical Circulatory Support B Billion NICU Neonatal Intensive Care Unit MSD Mid-Single Digit APV Aortic, Peripheral & Venous MDT Medtronic Bps Basis Points Org Organic Revenue Decreased Y/Y CABG Coronary Artery Bypass Graft Med Medical CAPEX Capital Expenditures Ops Operations Organic Revenue flat Y/Y CGM Continuous Glucose Monitoring MRI Magnetic Resonance Imaging CC Constant Currency OUS Outside the United States Organic Revenue Increased Y/Y COV Covidien MS Medical Surgical CE Conformité Europëenne PLC Public Limited Company Organic Weighted Average WAMGR CPV Market Growth Rate CRHF Coronary & Peripheral Vascular Cardiac Rhythm & Heart Failure NICU Neonatal Intensive Care Unit COVID-19 Coronavirus Disease 2019 Q Quarter NS Neuroscience Dev Developed Q/Q Quarter-over-Quarter CRM Cardiac Rhythm Management RAS Robot-Assisted Surgery EM Emerging Markets R&D Research & Development CRT-D Cardiac Resynchronization Therapy - Defibrillator RGR Respiratory, Gastrointestinal, & Renal EMEA Europe, Middle East, and Africa Rep Reported CRT-P Cardiac Resynchronization Therapy - Pacemaker RTG Restorative Therapies Group EPS Earnings Per Share SEC U.S. Securities & Exchange Commission Environment, Social & CSH Coronary & Structural Heart SCS Spinal Cord Stimulation ESG SG&A Selling, General & Administrative Governance CST Cranial & Spinal Technologies SHA Structural Heart & Aortic EU European Union Tech Technology CV Cardiovascular SI Surgical Innovations Ex-Vent Excluding Ventilator U.S. United States CVG Cardiac & Vascular Group TAA Thoracic Aortic Aneurysm FDA Food and Drug Administration VBP Volume-Based Procurement DBS Deep Brain Stimulation TAVR Transcatheter Aortic Valve Replacement FX Foreign Exchange WE Western Europe DCB Drug Coated Balloon TAVI Transcatheter Aortic Valve Implantation FY Fiscal Year WW Worldwide DIAB Diabetes TDD Targeted Drug Delivery GAAP Generally Accepted Accounting Principles YTD Year-to-Date Investigational Device DTM Differential Target Multiplexed Waveform TIR Time In Range IDE Y/Y Year-over-Year Exemption ECLS Extracorporeal Life Support URO Urology ID&E Inclusion, Diversity and Equity ENT Ear, Nose, & Throat IRS RS Internal Revenue Service 34 Q3 FY22 earnings presentation | February 22, 2022 Medtronic

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