BioNTech Results Presentation Deck

Need for Pandemic Vaccination Continues Global Vaccination Status ¹ Unvaccinated 36% (2.86 bn) 13 ■ 1 shot 1 shot 6% (0.46 bn) 2 shots 39% (3.08 bn) 3+ shots 19% (1.50 bn) ■2 shots 3 or more shots ■ Unvaccinated -36% of the world population remains completely unvaccinated. Only 19% of the world population has received a booster vaccination (3+ shots) ● ● Global Confirmed COVID-19 Cases² 10.5 bn Week of February 28 11.6 bn Week of March 7 1 New York Times COVID-19 Vaccination Tracker, as of March 22, 2022 2 World Health Organization COVID-19 Dashboard, as of March 25, 2022 3 The Centre for the Mathematical Modelling of Infectious Diseases at the London School of Hygiene & Tropical Medicine, as of March 22, 2022 12.6 bn Week of March 14 Infection rates remain high, driven by Omicron variant Global weekly infection rate in March 2022 is >170% higher than global weekly infection rate in Q4 2021 54 countries reported an R, >1 3 12 countries with cases doubling (or more) every week³ BIONTECH

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