LanzaTech Investor Presentation Deck
Rapid In Vitro Prototyping Platform to Inform Cellular Design
FOX
200000
***000
Enzymes
(Parts)
Biochemical
Pathway
(Engine)
Cell
(Chassis)
LanzaTech
Mix & Match Enzymes
Optimal Pathway Designs
MNOOOOO MATION OF FREE
Cell-Free
Synthetic Biology
Rapid prototyping of
optimal enzyme
combinations for a
biochemical pathway
before going into cells
Predictive to cellular
performance across
many pathways
Magnitude increased
speed and lower cost
Relative Score
Relative In Vivo Titers
Eco Garde
1.5
0.5
Example Pathway: Butanol
(4 steps x 6 enzymes x 6 levels = >800,000 combinations)
0
Thi
0
VAR 201
Correlation In Vitro to Cells
0.5
Relative In Vitro Titers
Cat
1
ACCUW
1.5
Ter
Pathway 1 (Butanol)
Pathway 2 (3-HB)
Pathway 3 (Hexanol)
Source: Karim, et al (2020) Nature Chemical Biology 16: 912-919, Voegeli et al (2022) Nature Communications 13:3058.
Cell image credit:Justin Muir. Other images generated with Biorender.com.
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