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Investor Presentation

Financial Snapshot ($s Millions except EPS) Revenue Revenue Growth Gross Margin (GAAP) Gross Margin (Adj.) 2019 $270.2 39%, 33% organic 55.9% 57.0% $36.1 $63.5 $21.4 $52.5 $0.44 $1.07 $528.4 49.2 $71.1 2020 $366.3 36%, 29% organic 57.2% 57.6% $69.8 $98.1 $60.0 $89.1 $1.11 $1.65 $717.3 53.9 $107.9 2021 Guidance* $625-$645 71-76%, 57%-62% organic 59%-60% 59%-60% $156-$161 $192-$197 $118-$122 $154-$158 $1.67-$1.74 $2.71-$2.78 $740-$750 57.0 $210-$215 Operating Income (GAAP) Operating Income (Adj.) Net Income (GAAP) Net Income (Adj.)¹ EPS diluted (GAAP) EPS diluted (Adj.)¹ Cash and Cash Equiv. YE Fully diluted shares YE (M) EBITDA (Adj.)² * FY 2021 Guidance as of 07/27/21 earnings call 1. Change in accounting for the treatment of tax on certain intangible amortization was made in 2019 2. Non-GAAP financial measure; see reconciliation tables in appendix 2020 Revenue Splits Consumables/Equipment ~77%/22% ~80%/20% ~70%/30% Biopharma/CDMO Clinical/Commercial RREPLIGEN INSPIRING ADVANCES IN BIOPROCESSING Additional 2021 Guidance* COVID-related revenue R&D % of revenue: Adj. tax rate: Cap Ex: $170-$180M 5.5%-6.0% 19% $55-$60 22
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