1Q21 Investor Update

MRTP DESIGNATION IS A CATALYST FOR ADDITIONAL GROWTH OPPORTUNITIES 22nd Century Group, Inc. MRTP designation opens multiple U.S. distribution, international licensing, and partnership opportunities for reduced nicotine tobacco technology and IP Advancing next-generation non-GMO plant research key to markets where non-GMO products are preferred, or GMO products are banned Successfully applied non-GMO technology to Bright and Burley varieties of tobacco and developed VLNⓇ 2.0 cigarette prototype ▪ Introducing reduced nicotine traits into Oriental varieties of tobacco 9

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