BenevolentAI Investor Day Presentation Deck
UC Target Identification workflow
Mechanism
1
4
Biological Question
Disease
Can we treat UC by reversing
chronic inflammation of the
colonic mucosa by targeting
pathways in colon epithelial cells
and tissue resident immune
cells?
Endpoint:
What we will measure
Sign
Experimental validation
Cell type
Endoscopic
Biopsy from UC patients
2
Target Identification
Predictive algorithms ran over
the curated knowledge graph to
identify potential targets,
aggregate findings and present
the most relevant ones to DD
scientists
200
Colonic mucosa tissue culture
and compound treatment
3
Target assessment and
validation tools presented
scientific evidence allowing
scientists to evaluate the
rational and opportunity for
progressibility
✔PDE10 has zero
linkage to UC in
all available
biomedical
literature
PDE10 inhibition promoted an
anti-inflammatory effect
Inflammatory cytokine
measurement
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