BioNTech Results Presentation Deck
Need for Vaccine-Adaptation to Omicron and Potentially Future
Emerging Variants
Omicron comprises almost 100% of sequenced
genomes in most parts of the world ¹
New variants more likely to arise from variants
that cause high infection rates 2,3
Real-world data suggest that vaccine-induced
immunity provides a higher degree of protection
than natural immunity4
As natural immunity wanes, vaccination extends
protection against reinfection 6-12
15
Share of Omicron variant in all analyzed sequences in
preceeding 2 weeks
No data 0%
10%
20%
30% 40%
50%
60% 70% 80%
Annual and/or seasonal boosters with variant adapted vaccines expected for the
foreseeable future for pandemic preparedness ¹3
13
1 Our World in Data. https://ourworldindata.org/grapher/covid-cases-omicron?country=GBR-FRA-BEL-DEU-ITA-ESP-USA-ZAF~BWA-AUS. Accessed 28/3/22; 2 Atlani-Duault L et al Lancet Public Health 6:e199-
e200; DOI:https://doi.org/10.1016/S2468-2667 (21)00036-0; 3 Otto SP, et al. Curr Biol, 2021; 31(14): R918-R929; 4 Shapira G, et al. Faseba 2022; 4: e22223. doi: 10.1096/fj.202101492R; 5 CDC
https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/vaccine-induced-immunity.html. Accessed 28/3/22; 6 MRC Centre for Global infectious Disease Analysis Report 49 https://www.imperial.ac.uk/mrc-
global-infectious-disease-analysis/covid-19/report-49-Omicron; 7 Hammerman A, et al. NEJM 2022; DOI: 10.1056/NEJMoa2119497; 5;
8 Yu, Y et al. Sci Rep 12, 2628 (2022) https://doi.org/10.1038/s41598-022-06629-2; 9 Lombardi A, et al. Journ Infect Pub Health 2021; 14(8): 1120-1122; 7; 10 Mayo Clinic. https://www.mayoclinic.org/diseases-
conditions/coronavirus/in-depth/herd-immunity-and-coronavirus/art-20486808.. Accessed 22 March 2022; 11 Abu-Raddad et IEClinicalMedicine 2021 May;35:100861. doi: 10.1016/j.eclinm.2021.100861. Epub 2021 Apr
28; 12 MRC Centre for Global infectious Disease Analysis Report 49 https://http://www.imperial.ac.uk/m rc-global-infectious-disease-analysis/covid-19/report-49-Omicron/ 6. Accessed 28/3/22; 13 Elliott P, et al
[Preprint] https://spiral.imperial.ac.uk/handle/10044/1/93887
World
90% 100%
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