40th Annual J.P. Morgan Healthcare Conference Presentation

Our Total Addressable Market by Franchise Repligen's TAM has significantly expanded to >$8B; we are taking share in $22B total market and delivering industry-leading revenue growth PROTEINS & AFFINITY RESINS Our Market Share: ~6% Our 3-year CAGR (2018-2021e): >25% PROCESS ANALYTICS Our Market Share: 4%-5% Our 2-year CAGR (2019 PF-2021e): >30% R REPLIGEN $1.9B 24% $1.1B 13% $8.1B $830M 10% CHROMATOGRAPHY Our Market Share: 12% -13% Our 3-Year CAGR (2018-2021e): >30% $4.3B 53% 2021e Overall Market Share = ~8% 2021e Revenue Growth of 79%-82% 2021e figures above are based on 10/28/21 guidance FILTRATION Our Market Share: ~9% Our 3-Year CAGR (2018-2021e): >60% 5

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