BenevolentAI Investor Day Presentation Deck

2. Target ID Target Progressibility Assessment (TPA): Identify the hypotheses most likely to succeed TECH APPROACH PREDICT TRIAGE ΤΡΑ ASSAY ✰ Programs / ALS Demo: Target progressability assessment list / ACKR3 (atypical chemokine receptor 3) Back to the list. ACKR3 TAntagonist Biology triage Opportunity to differentiate Patent landscape Selectivity Druggability Tractability Previous assessment (0) Selectivity Q Search for off-targets Symbol AVPR1A AGTR2 AVPR2 GALR1 GPR15 OPRD1 OPRK1 OPRL1 OPRM1 SSTR2 Off targets (59) Pocket Select ACKR3's pocket to compare it with pockets of off-targets Detected Pocket 1 Sequence similarity score ↓ Show multiple sequence alignment 94% 89%. 89% 89% 89%. 89% Y 89%. 89% 89% 89% Protein similarity Rows per page: View from Target Assessment Tool Feedback feedback ⠀ Protein O 10 ▼ 1-10 of 59 60%. >>> Your assessment Notes Selectivity 1 Off-targets (based on target homology and/or existing tools) for which selectivity is required, but is considered be likely unachievable. Off-targets (based on target homology and/or existing tools), for which selectivity is required, is considered possible, but has not been demonstrated with existing tools. x Chemical Space Plot for Druggability Activity DOI MW TPSA MW vs M Druggability evidence ligand data for ACKR3 (Click to link to publication) ISNEY W pActivity value 0+*&USOR Benevolent 37

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