BioNTech Results Presentation Deck

Omicron BA.4/5 RBD and NTD Sequences are distinct From BA.1 and BA.2 14 a BA.1 BA.1.1 BA.3 BA.2 BA.2.13 BA.2.12.1 BA.4/BA.5 NTD NTD T191 L24S del25-27 A67V 169-70 T951 G142D RBD viral membrane ə RBD del143-145 N211 del212 V213G G339D R346K S371L S371F S373P S375F T376A D405N R408S K417N N440K -90° NTD L452M L452Q L452R S477N| T478K E484A Q493R G496S SD1/SD2 Q498R N501Y Y505H T547K D614G H655Y N679K RBD, receptor binding domain; NTD, N-terminal domain Stalls et al., Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spike. Cell reports, 2022 HR1 P681H S704L N764K D796Y N856K Q954H N969K L981F RBD Omicron-BA.2 unique mutations Omicron-BA.2 common mutations Omicron-BA.1 unique mutations BIONTECH

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