BenevolentAI Investor Day Presentation Deck

Experimental Model System: Inflamed colonic mucosa biopsies from UC patients ● Cytokine production (ng/ml) Therapeutic anti-TNF monoclonal antibodies inhibit the spontaneous release of inflammatory cytokines and chemokines in ex vivo cultures of inflamed CD and UC tissue. 50 3 2 - O IL-6 ID2A V565 V565 V565 IgG IFX 300nM 30nM 100nM 300nM 67nM 67nM Source: Crowe et al 2018 Cytokine production (ng/ml) 40 35 30 25 20 15 IL-8 Mihali ID2A V565 V565 V565 IgG IFX 300nM 30nM 100nM 300nM 67nM 67nM Cytokine production (pg/ml) 100 90 80 70 60 50 40 30 20 10 0 TNFa ID2A V565 V565 V565 lgG IFX 300nM 30nM 100nM 300nM 67nM 67nM Benevolent 53

View entire presentation