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Pharma Update

Volume Number of pipeline assets in Phase I to III Roche ranks #2 in total pipeline volume Total number of pipeline assets by phase*, # Peer 1 12 39 Roche 11 36 Peer 2 11 56 Peer 3 15 29 36 Peer 4 11 30 36 Peer 5 19 25 27 Peer 6 9 29 25 63 63 Peer 7 5 26 30 61 Peer 8 10 28 18 56 Peer 9 st 4 22 29 55 Peer 10 3 19 33 55 Peer 11 12 23 14 49 49 Peer 12 LO 25 12 42 *Excludes pipeline products in pre-registration, registration and filed; Peer 1-12 are other large-cap Pharma Source: Pharmaprojects (February 2023), McKinsey attrition analytics Phase III Phase II Phase I 50 101 51 98 29 96 80 77 71 Roche 24

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