23andMe Investor Day Presentation Deck

CD200R1 is an Immune Checkpoint • CD200R1 is an inhibitory receptor expressed on T-cells and myeloid cells • CD200 is the only known ligand for CD200R1 in humans and is highly expressed in certain cancers Binding of CD200 to C200R1 decreases the ability of T-cells to recognize and kill cancer cells Several viruses, including HHV8 have co-opted CD200 analogues to suppress and evade the host immune response References: J Virol 2012;86:6246, J Virol 2004;78:7667, J Immunol 2005;175:4441, Structure 2013;21:820, JCI Insight 2018;3:e96836 CD200:CD200R1 Signaling Tumor cell CD200 Dok2 Reduced Anti-Tumor Immune Response CD200R1 RasGAP ERK T-cell Ras Copyright © 2022 23andMe, Inc. 23andMe® 36

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