BioNTech Results Presentation Deck

SARS-CoV-2 Epidemiology Changes Quickly: Vaccine Updates Need Timely Adaptation With the Pace of Virus 100 Proportion of Strains Omicron BA.1 Omicron BA.2 Omicron BA.2.12.1 BOOS Omicron BA.4 Omicron BA.5 75 50 25 0 Delta Dec 2021 Pre-clinical/CMC (proposed) Feb 2022 Clinical (current) ~8 months Sampling Date ~3 months Omicron Wave Circulating Strains Apr 2022 10 CMC, chemistry, manufacturing and controls GISAID Initiative database: https://www.gisaid.org/ (accessed June 20, 2022). USA Jun 2022 SARS-CoV-2 virus continues to evolve: Currently seeing new variant waves every ~3 months Variant vaccine adaptation timelines BIONTECH

View entire presentation