BioNTech Results Presentation Deck

Omicron BA.4/5 Monovalent and Bivalent Boosters in Mice Substantially Increase Omicron Neutralization Responses to All Tested Omicron Variants PVN 50 titer (Serum Dilution ¹) 105 104 103 10² 101 014 Compared to Monovalent OMI BA.1, BA.4/5 neutralizing titers increase by 11.3 fold (mono BA.4/5) or ~4.8 fold (bivalent BA.4/5) 0 P 4150 3490 1131 Wildtype BA.1 BA.2 018- 617 436 BA. BA.4/5 2.12.1 OMIBA.1 9870 4150 5869 4935 4935 Wildtype BA.1 BA.2 BA. BA.4/5 2.12.1 OMI BA.4/5 15 N=8 mice Balb/c mice. Mice preim munized with 2 doses of BNT162b2; boosters given at day 104 Pseudovirus neutralization assay; LOD, Limit of Detection; GMT, geometric mean titers 414 5869 2075 2691 3200 2075 Wildtype BA.1 BA.2 BA. BA.4/5 2.12.1 BNT162b2+ OMI BA.4/5 - LOD GMT BIONTECH

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