Investor Presentation

KEY INITIAL HEMP/CANNABIS PROGRAMS Application Zero/Undetectable THC and High CBD Zero/Undetectable THC and High CBG Stable High THC Yield Enhancement Powdery Mildew Resistance Divaric Acid (CBDV) - A non psychoactive minor cannabinoid with demonstrated anti-epileptic and anti-convulsive action Low Terpene and New Terpenes Profiles Targeted Benefit 22ND CENTURY GROUP Crop loss due to hemp going "hot" (exceeding 0.3% THC content) is a common industry issue. Zero THC helps growers stay under the allowed threshold, reduce crop losses, and reduce processing cost while high CBD and CBG increase yields. Consumers and CPG brands get zero THC content. Targeting disruptive lines with 30-40% stable yield of pure THC, well above unpredictable yields in current strains Increase in cannabinoid content in the flower and the rest of the plant for overall increased plant yields Crop loss can be as much as 25% of the crop yield depending on the region, growth method and year. Increase of yields of CBDV to a stable 4-8%, making it more accessible for use in medical research and commercialization. Reduce the terpenes responsible for undesirable aromas and the development of new combinations of terpenes desirable to consumers 22nd Century is advancing a broad funnel of hemp/cannabis plant lines and IP designed to address specific industry needs. 13

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