#1Repligen Announces Agreement to Acquire ARTESYN Biosolutions Tony J. Hunt, President and CEO Jon K. Snodgres, CFO October 27th, 2020 R REPLI OPUS R REPLIGEN#2Safe Harbor R REPLIGEN 2 This presentation contains forward looking statements which are made pursuant to the safe harbor provisions of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. These statements are subject to risks and uncertainties which may cause our plans to change or actual results to differ materially from those anticipated. In particular, unforeseen events outside of our control may adversely impact future results. Additional information concerning these factors is discussed in our reports filed with the Securities and Exchange Commission including recent Form 8-Ks and our most recent Annual Report on Form 10-K. The forward looking statements in this presentation reflect management's current views and may become obsolete as a result of new information, future events or otherwise. We may not update such forward looking statements to reflect a change of events or circumstances that occur after the date hereof, except as required by law. The industry and market data contained in this presentation are based on management's own estimates, independent publications, government publications, reports by market research firms or other published independent sources, and, in each case, are believed by management to be reasonable estimates. Although we believe these sources are reliable, we have not independently verified the information.#3Strategic Move to Expand Single-Use Bioprocessing Systems, Components and Flow Paths R REPLIGEN 3 Gold Standard in Single-Use Systems ARTESYN Biosolutions is an innovator and a market leader in fully automated CGMP single-use Chromatography, Filtration and Buffer/Media Prep Systems and Flow Paths Vertical Integration with EMT and ProConnex® EMT key provider of silicone liners and assemblies (July 2020) Complements and expands ProConnex flow paths Full control of supply chain Complements, Expands RGEN's Systems Portfolio beyond Hollow Fiber Filtration Adds Systems for Flat sheet Filtration, Chromatography and Buffer Prep Adds leading innovator in downstream continuous manufacturing Future integration of FlowVPE to further differentiate RGEN Systems Foundation for Systems in Gene Therapy Filtration and Chromatography solutions Very low hold up volumes - minimizes product losses and differentiates versus competition Expands Total Addressable Market Adds ~$0.2B to addressable market bringing total to ~$3.2B Addresses all biologic types mAbs ● ● rProteins Vaccines Cell & Gene Therapy Meets Repligen's M&A Criteria Highly differentiated technology Addresses gaps in Filtration and Chromatography Systems Strong revenue growth Accretive to adj. EPS in 2022 Market leader, SU innovator, Expands RGEN Systems, Accretive 2022 ARTESYN Biosolutions#4ARTESYN BioSolutions Meets Repligen's Acquisition Criteria R REPLIGEN 4 Technology leadership in bioprocessing A gold standard in Single-Use Systems design and performance, highly differentiated ✓ Strengthens and expands Repligen portfolio ● ● Addresses gap in Filtration with TFF Flat Sheet System Expands Systems portfolio Filtration, Chromatography, Media/Buffer Prep, Custom Continuous Manufacturing Supply chain control Integrates EMT and ProConnex flow paths in Systems portfolio Operational and commercial leverage ● ARTESYN has minimal salesforce today - leverage Repligen's commercial team Strong operational synergies in Systems and Flow Path assemblies Growing revenues, improving margins as ARTESYN business expands 2021 focus on building commercial and expanding pipeline opportunities Leveraging EMT - expands margins and secures the supply chain for key components Expected to be breakeven to adjusted EPS in 2021 and accretive in 2022 ~$200M purchase (~$130M cash, $70M shares), 6x-7x 2020e Revenue ARTeSYN Biosolutions#5ARTESYN BioSolutions Company Profile R REPLIGEN 5 Filtration Chromatography State of the Art Filtration and Chromatography Systems Customizable, Easy to Use, Flexible Headquarters: Waterford, Ireland Founded: 2015 by Michael Gagne Employees: 130 Headquarters: Waterford, Ireland Manufacturing: US (CA), Ireland, Estonia Sales offices: US Distributors: US, EU https://www.artesynbiosolutions.com Revenue ($Ms) ● ● ● Accelerated revenue growth in 2020 ● $40 $35 $30 $25 $20 $15 $10 $5 $0 ● $8.5 2019 Products snapshot Single-Use Systems supports 15L-2000L Lab-scale through CCMP manufacturing Fully automated Systems for Filtration, Chromatography and Buffer/Media Prep Low hold-up volumes Precision and accuracy in gradient elution Single-Use Consumables incl. Smart Valves and Liners, Flow Paths Customer Call Points $30.0 est. 2020e Process Development $33-$36 est. Manufacturing Biopharma & CDMOs 2021e ARTESYN Biosolutions#6ARTESYN Biosolutions Revenue Sources R REPLIGEN 6 BioProcess Systems & Flow Paths ~50% TFF Filtration Systems Chromatography Systems Buffer/Media Prep Systems 6. DOWNSTREAM FILTRATION AE-403 TE-401 AE-404 0 DOWNSTREAM CHROMATOGRAPHY Over Molded Tubing Sets from EMT DOWNSTREAM FINISH FILLING Components and Consumables ~50% Single-Use Flow Paths Valves, Valve Liners, Flow Path Exoskeletons Total Projected Revenue ~$30M in 2020 - ARTeSYN Biosolutions#7Favorable Financial Impact of ARTESYN Biosolutions Acquisition R REPLIGEN 7 Expected to add approximately $33M-$36M of revenue in 2021E Gross margins currently below Repligen corporate average with goal of >50% in 2021 2021 investment focus: commercial integration and commercial pipeline build out Expected to be breakeven on adj. EPS in 2021E, accretive in 2022E Projected revenue synergies of ~$10M over the three-year period starting 2021 ARTeSYN Biosolutions#8Questions? Contact Investor Relations [email protected] 781-250-0111 © 2019 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property of Repligen Corporation and/or its affiliate(s) or their respective owners. www.repligen.com R REPLIGEN#9Questions? Contact Investor Relations [email protected] 781-250-0111 © 2019 Repligen Corporation. All rights reserved. The trademarks mentioned herein are the property of Repligen Corporation and/or its affiliate(s) or their respective owners. www.repligen.com R REPLIGEN